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Cat. No.	Product Name	Target	Signaling Pathways
T21995	XAP044	GluR	Neuroscience
	XAP044 是高效的选择性mGlu7拮抗剂。代谢型谷氨酸受体亚型 7 是哺乳动物 CNS 中神经传递的重要突触前调节剂。它在啮齿动物行为测试中表现出较好的大脑暴露、广谱抗应激、抗抑郁以及抗焦虑作用。
T61528	FGFR-IN-7
	FGFR-IN-7 (compound 17) is an orally active, potent FGFR modulator with the ability to penetrate the blood-brain barrier. It exhibits neuroprotective properties, enhancing brain exposure and decreasing the likelihood of phospholidosis. FGFR-IN-7 proves valuable for research on neurodegenerative diseases [1].
T35873	C19 Ceramide (d18:1/19:0) C19 Ceramide (d18:1/19:0)
	C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.[1],[2],[3] It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 and 37%, respectively, following chronic ethanol exposure.[2] C19 Ceramide is also increased in mouse hearts following administration of angiotensin II.[3]
T79524	JPC0323	5-HT Receptor	GPCR/G Protein; Neuroscience
	JPC0323为双5-HT2C/5-HT2A受体正变构调节剂，具备良好的靶向性、血浆暴露水平及脑部穿透能力，适用于神经系统疾病研究领域。
T10443	Aβ42-IN-1 free base	Others	Others
	Aβ42-IN-1 free base是一种口服活性的γ-secretase调节剂，具有高暴露度。该化合物能显著降低小鼠脑中Aβ42的水平，IC50为0.091 μM，显示出在阿尔茨海默病研究中的潜力。
T63216	γ-Secretase modulator 11
	5-{8-[（3，4'-二氟[1，1'-联苯]-4-基）甲氧基]-2-甲基咪唑并[1，2-a]吡啶-3-基}-N-甲基吡啶-2-甲酰胺（1o）具有较高的体外效力和脑暴露效果，能够使脑Aβ42水平的明显降低，且对细胞色素p450酶无抑制作用。此外，化合物1o 在AD 模型小鼠中表现出优异的抗认知缺陷作用。
T68356	AM-3189
	AM-3189 is a potent and selective GPR40 Agonist with minimal CNS penetration, superior pharmacokinetic properties and in vivo efficacy comparable to AMG 837. AM-3189 maintains the in vivo efficacy of AMG 837 while displaying a superior pharmacokinetic profile and minimal CNS exposure. Similar to AMG 837, while highly potent on GPR40, AM-3189 was highly selective over the closely related GPCRs, GPR41 and GPR43. 13kdemonstrated low clearance, moderate volume of distribution, and good oral bioavai...
T79666	WLB-89462	Sigma receptor	GPCR/G Protein
	WLB-89462（Compound 20c）是一种高选择性σ2受体配体（Ki：13 nM），展示出神经保护活性，并能有效改善由Aβ肽引发的大鼠短期记忆障碍。该化合物拥有出色的ADMET特性，包含良好的溶解度、无CYP抑制作用、优异的代谢稳定性、高渗透性、脑部可渗透性以及在啮齿类动物中经口服途径高暴露量。
T36701	Phosphoramide mustard (cyclohexanamine)
	Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA damage and elicits the ovarian DNA repair response[1][2]. Phosphoramide mustard cyclohexanamine causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication[1].Phosphoramide mustard cyclohexanamine destroys rapidly dividing ce...